Sunday, March 31, 2013

Eiffel Tower evacuated after bomb threat

PARIS (AP) ? Police say the Eiffel Tower has been evacuated after an anonymous caller phoned in a bomb threat.

A Paris police official says nearly 1,400 people have been evacuated following a request from tower operators after the warning Saturday. Police then searched the monument with sniffer dogs for possible explosives, and set up a broad security perimeter.

French authorities have stepped up counterterrorism measures in recent weeks amid heightened concern about threats to France over its military campaign against al-Qaida-linked fighters in Mali which began more than two months ago.

The tower is occasionally evacuated because of such warnings ? at least once last year and twice in 2011. The 324-meter (1,063-foot) tower is one of the world's top tourist attractions, with millions of visitors a year.

Source: http://news.yahoo.com/eiffel-tower-evacuated-bomb-threat-204807606.html

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The next $1B markets in tech - Business Insider

Reuters

Social e-commerce is going to be BIG.

New tech industries start small but can grow into permanent, billion dollar slices of infrastructure. Sometimes that seems to happen overnight ? like with smartphones.

And sometimes it takes years ? like with the dumb phones that grew like mold from the mid-1990s through the late 2000s.

And now, for example, the prevalence of smart mobile devices has spurred the mobile app industry, an entirely new piece of infrastructure which supports thousands of companies and billions of dollars in sales.

There is a discussion going on over at Quora about which industries are poised to gain the next $1 billion.

We pulled out a few of the most interesting and explored why they're set to explode.

Source: http://www.businessinsider.com/the-next-1b-markets-in-tech-2013-3

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Saturday, March 30, 2013

Vaishno Devi Helicopter Booking

By: anny mack Vaishno devi has always been one of the well-known pilgrimage location where an incredible number of enthusiasts go every season. As opposed to the many pilgrim areas in India, the Vaishno Devi which is located in Jammu and Kashmir is a shrine located 5, 300 ft above. The shrine is located exactly 61 kms away from Jammu and the last 13 Kms of the trip has to be finished by pilgrims via feet. Although there are other features available to trip to the shrine many choose getting the delights of goddess via feet. This reveals their highest commitment towards the goddess. We often wonder is it necessary to go on a pilgrimage, but pilgrimages should not be done in power. Only if an individual is enthusiastic about doing that he must go for it. Individuals go on pilgrimages because that gives them everlasting pleasure and pleasure. In this damaged and stress loaded lifestyle the only factor that can provide serenity is viewing a sacred shrine which is Vaishno Devi.
Many people try walking until the cave shrine while few others who have wellness problems take horse or choose to go by helicopter. The Vaishno devi helicopter bookings can be done easily either through the internet or phone call. This way of travelling to this shrine via helicopter proves to be very useful for people who are not fit enough to climb and walk. There is a different en altogether different excitement in getting the blessings of the goddess. As people from all over the world visit this temple many people opt for the helicopter service. Earlier there was no such facility and every one had to walk up to the shrine or ire a pony. But since the helicopter service have started visiting the shrine has indeed become very easy.
Earlier however, the facilities were not as excellent as the ones available these times. Individuals previously used simply keep walking kilometres together to get one glance of the Vaishno Devi. But all thanks to the transportation program. As we know Jammu is one position which joins to other locations very easily many pilgrims make sure to visit the shrine via Jammu. Choosing a Vaishno devi helicopter service in itself appears to be very interesting. Those individuals who have never in their life travelled via a helicopter must surely try it once in their lifetime as it is truly a very blissful experience.
The benefit behind viewing the Vaishno devi by helicopter is it helps you to not waste time. Though it is a bit expensive it allows pilgrims arrive to their location easily without any problems. The resorts near the shrine too are very easily available so tourists need not fear about their accommodation. All types of traditional, economic and high-class resorts are available and the arranging for these can be done either through phone or via the internet very easily. During the off period the count of pilgrims is relatively less so you could well plan your trip Vaishno devi helicopter booking in advance for a comfortable travel.

About the Author:
Anny Mack is a well known author and has been writing articles for providing you cheap packages of Mata viashno devi yatra, Vaishno devi helicopter bookings and Vaishno devi helicopter service, Vaishno devi by helicopter, Katra Hotels, helicopter services booking online.

Article Originally Published On: http://www.articlesnatch.com


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EBay CFO sees profit per share up 15 to 19 percent a year over next 3 years

March 28 (Reuters) - Rory McIlroy, playing for the first time since losing his world number one ranking earlier this week, got off to a shaky start at the Houston Open on Thursday where he dropped three shots over his opening eight holes. The 23-year-old Northern Irishman, who was replaced atop the world rankings by Tiger Woods this week, struggled to find his rhythm on an ideal day for low scoring at the Redstone Golf Club in Humble, Texas. He bogeyed the par-four second hole and made a double-bogey seven on the eighth hole to limp to the turn at three-over. ...

Source: http://news.yahoo.com/ebay-cfo-sees-profit-per-share-15-19-202523200--sector.html

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Mike Kuhn: Riding, Race Promotion, and the Economic Power of ...

wicks
Barry Wicks at the 2012 TSE. Photo via TSEpic.com

A lot of people love cycling. For one reason or another, it?s a sport that lends itself to obsession. Mike Kuhn has been showing his love and obsession with over two decades of riding, racing, race promotion, and advocacy. He?s perhaps best known for putting on the Transylvania Epic, a seven day mountain bike stage race in the heart of Pennsylvania. He?s also the man behind IronCross, an endurance cyclocross race, along with many more road, cross, and mountain bike races through the years. And though two decades of race promoting is inarguably an example of giving back to the bike community, Mike is also heavily involved in trail advocacy. He and Transylvania Epic co-founder Ray Adams launched a nonprofit The Outdoor Experience Organization in 2009 to raise funds for mountain bike trail building, maintenance, documentation and outreach in Pennsylvania. I had the chance to speak with Mike about his history in bike racing, the rapid growth of the Transylvania Epic and endurance racing, his vision to revive a small PA mining town with a high-quality trail network, and more.

What?s your background in riding and racing?

I got into riding just before college, so about 23 years ago. I raced for the Bucknell cycling team in school. After college I didn?t know what to do, so I raced more and more. I got pretty good and got to tour around and race in different parts of the country. I was more road focused at the time, but was still mountain biking.

It was in college that I promoted my first event. I enjoyed that experience and had the opportunity to hold some races on my in-laws? farm. We?ve got a 100 acre farm and we?ve been putting on events for 15 years out there. I just love this sport; I love all the parts of the sport.

It was maybe 15 years ago that I heard about Trans-Germany, one of the first mountain bike stage races. That planted a seed for me that very slowly germinated into the Transylvania Epic.

Were you organizing mountain bike races on the family farm?

Yeah, we were doing mountain bike races. Through the years I?ve done a little bit of everything with promoting and racing. Cross, road, mountain bike. The farm has been a spot for both mountain biking and cyclocross racing.

One of the first mid-Atlantic cyclocross events was held there. That?s going back 10 years. We?ve had a stage race there. Now we have the International Intergalactic Global Open Mountain Biking Relay Championship of the Multiverse. And we have a cross version of that too. You?re pretty much allowed to call yourself whatever kind of championship you want and I think we?ve covered all the bases. I believe it makes the winners of the event the undisputed champions of everything. So we?re stoked to have that at the farm in little Marysville, Pennsylvania.

mikekuhnTell me about getting Transylvania Epic off the ground. You mentioned you were inspired 15 years ago to create a stage race, how did it go from there to reality?

I?d seen some of those very early endurance races. I think there was a Tour VTT. Trans Germany was one of the early one. I know how good the riding is in Pennsylvania.

The East Coast gets a little shortchanged sometimes, but I knew we have thousands and thousands of miles of trails and dirt roads that are world class.

Over the intervening years we started a team called Visit PA. It was sponsored by the Department of Tourism. It was a pretty successful team for a while. I got into that with a good friend of mine Ray Adams. We ran the team and as the team was running out its course, we got to talking about trying to launch this multi-day stage adventure in PA.

We obviously had pretty good contacts with the Department of Tourism. And they expressed some interest in it. The original idea and approach was going to be much different than what we have right now. This was the year before the economy crashed and we were in talks with the State to have a more standard-model mountain bike stage race. You have tent cities and you move from place to place each stage. The economy fells apart, the impetus dried up very quickly for that kind of race, and we had to reevaluate where we were.

It took a bit of scrambling to figure out how to do the race. We looked around the state to figure out the best place to hold the race. State College has, since the dawn of mountain biking, been an integral place in PA for the sport. The early Coburn races, the first 100 mile races with the Wilderness 101. Those style events have been going on there for a really long time and there?s a wonderful network. There?s an incredible club up there, the Nittany Mountain Bike Association.

So we found this scout camp outside of State College, called the Seven Mountains Scout Camp from the Juniata Boy Scout Council. It is right smack-dab in the middle of amazing trails. We?ve been able to stretch the race to seven days, returning to the camp every night. The stages are 25-45 miles, with very little repetition throughout the week. It?s a real wonderful resource to have all that stuff in one place.

The event is great. People love coming to camp there. They love the camaraderie that a week of mountain bike adventures brings. They say it?s kind of like the summer camp experience they remember from their early teenage years, translated to mountain biking plus with beer. It?s just really fun.

You sort of just hit on why Transylvania Epic is succeeding. But, it?s been impressive how much its grown over the course of just a few years, from a relatively-small event with mostly regional-level pros to one with an international draw. Why do you think the race has grown so quickly?

We work hard at it and that?s part of it. It?s a year-long process to pull the thing together, or more. I?m already working on 2014 and we?re still a few months out from the 2013 race.

We?ve developed some wonderful relationships with out partners. NoTubes has been incredible right from the get go. Dirt Rag has been a big supporter. PacTimo, too. All these guys who came on board early. Hammer Nutrition have been wonderful. It?s evident the kind of support they?re giving when you come to the event and see the things we?re doing.

BMC came on board this year. SRAM and Answer Products did too. Having that kind of support from the industry has been huge. We?ve also developed some great press relationships, in addition to Dirt Rag. We push that hard and it develops the exposure for the event, but also the participants. These guys come, they love what they?re doing. The word of mouth has been really good. But also, for someone like Jeremiah Bishop or Amanda Carey who come out and do the event, they?re getting eight or nine days of national and international level coverage for themselves and their sponsors.

It?s kind of all built on itself. Those guys want to come and get that exposure. It helps us produce press for the event that people want to read, that helps us tell the story of the event. And people think its fun. They come out and enjoy themselves. Even the international caliber pros, they love to ride their bikes and that?s what they?re doing and the story spreads.

I think the key to our success is that it?s really, really fun. I keep coming back to it, but it?s the fun you have in a week of mountain biking on great trails.

mikeatTSE

Mike with a racer at the 2010 TSE. Photo via thesecretlifeofadirtdiva.com

Endurance racing in general seems to be blowing up these days, with lots of former cross country racers focusing on longer events. What?s so appealing about 100+ miles days of offroad racing?

I think it?s the adventure. The word?s been overused, but it?s the epic feeling you get from being out there for four hours or 24 hours or a few weeks if you?re doing a race like the Great Divide. There?s a different atmosphere around the events that lends to their success. There are people there for the experience and the adventure and that makes the atmosphere a little more fun perhaps. People are more willing to hang out afterwards. It?s not just come in, race for an hour or two, go home. It?s more culture, it?s more tribe, it?s more soul; however you want to say it, that?s a really appealing part to the endurance stuff.

It?s suffering just like anything. If you go hard and you go long it?s going to hurt, and that appeals to people. All of us doing endurance sports are a little strange that way.

Also, the challenge is there. If you?ve been racing, and especially if you?ve been racing cross country for a long time, you get to the point of wondering what else you can do with your bike. We?re seeing the same thing happen with cyclocross, too. People have these bikes that are awesome. It?s really fun to do cyclocross, it?s a wonderful sport. But you race for a while and you start wanting to see what else is out there. That?s why the gravel-style events are taking off. That?s why the ultracross series and our event Iron Cross are picking up. It?s the next step for a lot of people.

I understand you?re involved in an effort to build a new trail network near Harrisburg. Tell me about that project.

When we founded Transylvania, we founded it to raise funds for nonprofit the Outdoor Experience Organization to do trail enhancements and creation in Pennsylvania. Everyone who?s coming to TSE, sponsors who support it; they are helping with this mission of making more and better trails in PA. One area we?re particularly interested in working on is outside of a town called Lykens. Lykens is an old mining town, coal mining. The extraction companies left in the early 80s. The town has survived, but doesn?t have the feel that it once did.

There is an IMBA Epic trail called the Rattling Creek Trail Network outside of Lykens. It?s got about 30 miles of really great stuff. We put on the Rattling Offroad Weekend there in August. A lot of people consider it the best endurance course on the east coast. I think that speaks very highly to its appeal.

The problem is, it?s not connected to Lychens or the other towns in this valley. It?s not connected to the town and there?s a lot of people in the town that don?t even maybe realize there?s this wonderful resource there. We see a lot of potential to help the town of Lykens and the Lykens Valley move into a recreation based economy, or at least have an economic engine from outdoor rec. So that?s our goal, to make the trail connections in the Valley; hopefully have some other towns come on board.

The Department of Conservation and Natural Resources (DCNR) is excited about this. They have several tracts of land that they?re interested in having us use to expand the network. We think we can at least double the mileage of trails and create green and blue level cross country trails. A lot of what?s up there right now I?d consider blue to black XC. There?s potential for some flow trails. There?s a lot of elevation there that hasn?t been utilized that we can do some really cool things with.

Hopefully we can create a major East Coast destination out of this. There?s a possibility here to connect these towns in such a way that you could start in one, ride to the next one for lunch. There?s a rail-trail going in so that family can come out and you can do some riding with them. It?s a major goal of ours to do everything we can to make this happen. We?re working with Lykens to do a feasibility study for them. We?ve had a professional trail builder come in and take a look. We?re starting to get input from different user groups about what they would like to see.

It seems like this sort of conversation about the economic impact of cyclists is happening more and more these days. It?s mostly been in the context of long-distance bike tourists who ride through small towns and spend money. Have you heard about other trail network projects having an impact on rural towns?

It?s certainly been proven in a few places. In Colorado, Leadville is good example of a place that?s had a lot of success with event-based recreation. It?s helped to attract other users. The events they hold there bring in thousands of people a year, which has done a wonderful job of driving that economy. There?s the Bailey Hundo in Pine, Colorado. They are working really hard in a similar mode. These Colorado towns and some others out west have a similar story. It was an extraction economy for a long time and so what?s there may not be developable.

In Lychens, much of the land is tied up in watershed property, DCNR property, and PA State Gamelands property, so it?s not going to be developed. It?s old coal mining so it?s maybe not great for a whole lot of other uses. You drive into this valley and there?s nothing but these two ridges on either side of it. It could be a playground for outdoor recreation.

Raystown, which is about two hours up the road from Lychens, was a very successful project. It?s kind of unique in that those trails sit by themselves. There is no town next door to it. But the studies being done are showing that within one to two years, the project, which cost three-quarters of a million dollars has paid for itself in increased revenue in the area from recreational spending. And it?s primarily mountain bike use on those trails at Allegripis.

I think the evidence is out there that this works. It?s more than just putting in the trails. There has to be a plan for the trails, a plan for the marketing, a plan for the maintenance. Unfortunately it?s not just build it and they?ll come. But as you go down that road and you put on some events there and get the marketing, it can work really, really well.

Is there anything else you want to say about your work, your racing, your mountain biking?

I don?t know if there?s a whole lot to add there, but I will tell you about one thing we?re getting ready to do with Transylvania. As I mentioned, we brought BMC in as a sponsor this year. They?re doing some very cool stuff for the event. The thing I?m most excited about is they?re donating a bike we?re going to raffle off. You?ll be able to buy tickets at events throughout the year and on the website, TSEpic.com. It?s going to be a 2014 model, same level that the team?s riding, which is the TE02 or FS02 model. And we?re going to couple that with entry to the 2014 Transylvania Epic. And proceeds are all going back into trail networks. It?s an opportunity to come do a fantastic event, maybe get a really cool bike out of it, and contribute to some really good things happening with mountain biking here in the state.

Source: http://www.thebicyclestory.com/2013/03/mike-kuhn/

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Friday, March 29, 2013

How Does Early Childhood Education Benefit Children? | Accredited ...

Early Childhood EducationIf you are interested in finding a career in education, you will almost certainly need to earn a degree in a field like early childhood education or educational administration first. Many people are curious about why this is necessary, and you might wonder why a degree in education is more valuable than a degree in literacy, history or any other specific subject matter. A degree in childhood education is important because it prepares teachers for success in the classroom, and it will benefit the students in many ways. Here are some of the ways that an online degree in early childhood education is such a good idea.

How Does Early Childhood Education Benefit Children?

The main way that early education training benefits children is by turning out teachers who are aware of what it takes to bring success to the classroom. Aspiring teachers will learn how to identify learning disabilities in students, manage classrooms efficiently and encourage students to do well. In addition, these courses will make sure that anyone who eventually becomes a teacher is equipped to take on the challenge, and parents can feel comfortable sending their children to school each day.

What Degrees are Available in Early Childhood Education?

Anyone who is interested in becoming an early childhood educator can choose from a number of degrees in the field. The three most popular options include the associate degree, the bachelor?s degree and the master?s degree. An associate degree takes just two years to complete, but it may only prepare students for assistant teaching positions. A bachelor?s degree is Early Childhood Educationmandatory for teachers, and some school districts will also request that teachers have a master?s degree before they are hired on a permanent basis.

What are the Career Prospects for Graduates?

After you graduate with a degree in early childhood education, there are a number of career opportunities available. The most common career choice is obviously that of elementary school teacher, but that is far from the only choice that you have for a career. Other popular options that you might be interested in include that of curriculum developer, educational administrator, group childcare worker or even social worker. Whatever you decide, you will be able to make an impact of the lives of children and help them to succeed in school and in life.

What are the Benefits of an Online Degree?

If you know that you want to pursue a career in early children education, you will be able to choose between an online degree and a traditional degree offered through a brick and mortar college campus. Online degrees are becoming increasingly common thanks to their flexibility, their affordability and their convenience. If you don?t live close to a college campus, if you already hold a full-time job or if you have family obligations, then an online degree can be exactly what you need to secure a new career without sacrificing your priorities.

Deciding to pursue an online degree in early children education will help you to achieve your future goals, but it will also have a positive impact on hundreds and possibly even thousands of children over the course of your working career. Find the degree program that can help you reach your goals at Accredited Online Colleges.


Tags: Accredited Online Colleges, Early Childhood Education, Education Degrees, Online Degrees

Source: http://blog.accredited-online-colleges.com/7765/early-childhood-education-benefits-children/

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Video: HBT Extra: Not just the East's beasts

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Source: http://nbcsports.msnbc.com/id/21134540/vp/51354436#51354436

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Lawsuit against Yankees GM Cashman is dropped

(AP) ? The mother of a woman accused of stalking New York Yankees General Manager Brian Cashman has abruptly dropped her lawsuit against him.

The New York Post (http://bit.ly/11RiVwB ) reports that Caroline Meanwell filed documents in court Tuesday to drop the lawsuit.

The suit had alleged that Cashman conspired with her daughter's former therapist and his legal team to trick Meanwell into calling 911 to discredit her daughter, who had claimed to have a nine-month affair with Cashman.

The suit claimed Meanwell was coerced into telling authorities her daughter, Louise Neathway, was going to kill herself so Neathway would be institutionalized.

Prosecutors say Neathway stalked Cashman and got him to pay her $6,000 by threatening to damage his reputation.

Neathway has pleaded not guilty.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-03-28-Yankees-Cashman-Harassment/id-3b5977a8bf0e47ddb30a73542bb14f57

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Wednesday, March 27, 2013

An Arbitrary Number of Years Since Mathematician Paul Erd s s Birth

Today would?ve been the 100th birthday of the Hungary-born mathematician who published so many papers--and many with such great impact--that a playful measure of one?s academic affiliation with him has been created


Paul Erd?s Paul Erd?s at a student seminar in Budapest, Fall 1992. Image: Wikimedia Commons/Kmhkmh

I take issue with the celebration of Paul Erd?s? 100th birthday.

Not the celebration itself, but the number. Why 100? The number 100 was chosen, of course, because 10 is the base unit of our number system: We have 10 unique symbols (0-9) that can be combined to represent any conceivable number. Ten units of 10 is 100, so it?s a nice, neat factor. If we used a base 12 system, we would have 12 unique symbols, and we?d be celebrating anniversaries of 144 years. But I can?t find any particular significance about 100 for Erd?s.

Erd?s was born in 1913 in Hungary to Jewish parents, both mathematics teachers. He moved to Manchester, England, in 1934 for a post-doctoral appointment, but also spent time (unofficially) working in London, Cambridge and Bristol--establishing a trend of bouncing from institute to institute that would continue for the rest of his life. Erd?s did not return to Hungary until 1945, after Soviet troops liberated Budapest from the Nazis. Throughout his life he spent time living in the US, Israel and Britain, and visited Hungary often. But he had no permanent residence. He lectured, taught and worked at dozens of universities, but never held a permanent position at any of them. He died in 1996 of a heart attack while attending a conference in Warsaw.?

Next year will mark Erd?s?s 101st birthday, which would be better than celebrating his 100th birthday, because 101 is a prime number. You can?t divide 101 by anything but 1 and itself and still get a whole number (where 100 is the product of 2 x 2 x 5 x 5). Erd?s once told his biographer, Paul Hoffman, in a somewhat beautiful and somewhat sad sentiment that prime numbers were his best friends.

A large portion of Erd?s?s work involved prime numbers. The first significant theorem he ever proved, at age 17, stated that between any number and its double, there is at least one prime number. The Russian mathematical giant Pafnuty?Chebyshev had already proved this theorem, called Bertrand?s conjecture, 80 years earlier, but Erd?s proof was simpler and clearer. Erd?s later did a similar job of simplifying the prime number theorem, which reveals how prime numbers will be distributed. Close to zero, prime numbers are common: 2,3,5,7, et cetera. As one climbs higher and higher, however, prime numbers occur more infrequently. (The prime number theorem doesn?t? show how to find those numbers, which are infinitely abundant. The largest known prime number is 257,885,161 ? 1, which has over 17.4 million digits).

Reducing proofs and theorems to their ?elementary? state was a particular talent of Erd?s?. He once wrote a simpler proof of a theorem in a paper he was supposed to be refereeing. Erd?s believed that ?the Supreme Fascist? (God) kept a book of mathematical proofs in their most perfect, simplified states, and it was the task of mathematicians to transcribe the pages from this book.

In some respects, zero was a rather significant number for Erd?s. Along with his peripatetic proclivity, he never married, never had children, never bought a home and never had a regular job or very much money. Instead he traveled, carrying all his worldly possessions in two suitcases, making a temporary home with collaborators. This lifestyle took him throughout the U.S. and Europe. At last count, he published papers with 511 people.

Erd?s? terrible behavior as a house guest is legendary: opening a carton of tomato juice by cutting a hole in it and not bothering to clean up the mess; banging pots and pans at 4:30 in the morning to wake everyone so they could continue their work.

Despite his obnoxious behavior, Erd?s was usually welcomed back, and remained friends with most of the people he visited. Reportedly, he was a radiantly happy person, a delightful collaborator, and had a gift for getting people to do mathematics to the best of their capabilities.? In fact, a more fitting celebration for Erd?s might be December 26, 2039, or 1,521 months after his birth: 1,521 is the total number of papers he collaborated on, which is more than any other mathematician in history.

Source: http://rss.sciam.com/click.phdo?i=90080126ef0acfa837c0b17467a33421

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Vizible Is the Location-Based, Picture-Only Twitter Client of Your Dreams

When you search Twitter for specific hashtags, you'll find yourself drowning under a sea of useless results. And there's no way to narrow your search to images only, if that's what you're in the market for. Fortunately for you, Vizible takes on that role and gives you a clean view of nothing but images, all happening right around you. More »


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/wwlP73RWDBg/vizible-is-the-location+based-picture+only-twitter-client-of-your-dreams

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BoE's King says global crisis "far from over"

In his new cover story for New York magazine, Joe Hagan offers the most in-depth look at the Today?show ratings?disaster that has created Matt Lauer's weeks-long attempt at image rehabilitation, and it's now clear that the defining moment that brought the morning show crashing own to Earth ? the exit of Ann Curry ? was something of a cross between the fourth circle of Hell and?and running with the Heathers?in high school: Curry got pranked, she got her clothes made fun of, she was prevented from reaching out to Robin Roberts, and her legacy lives on as a ...

Source: http://news.yahoo.com/boes-king-says-global-crisis-far-over-180418323--business.html

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Research provides clues to alcohol addiction vulnerability

Mar. 25, 2013 ? A Wake Forest Baptist Medical Center team studying alcohol addiction has new research that might shed light on why some drinkers are more susceptible to addiction than others.

Jeff Weiner, Ph.D., professor of physiology and pharmacology at Wake Forest Baptist, and colleagues used an animal model to look at the early stages of the addiction process and focused on how individual animals responded to alcohol. Their findings may lead not only to a better understanding of addiction, but to the development of better drugs to treat the disease as well, Weiner said.

"We know that some people are much more vulnerable to alcoholism than others, just like some people have a vulnerability to cancer or heart disease," Weiner said. "We don't have a good understanding of what causes this vulnerability, and that's a big question. But if we can figure it out, we may be able to better identify people at risk, as well as gain important clues to help develop better drugs to treat the disease."

The findings are published in the March 13 issue of the Journal of Neuroscience. Weiner, who directs the Translational Studies on Early-Life Stress and Vulnerability to Alcohol Addiction project at Wake Forest Baptist, said the study protocol was developed by the first author of the paper, Karina Abrahao, a graduate student visiting from the collaborative lab of Sougza-Formigoni, Ph.D, of the Department of Psychobiology at the Federal University of Sao Paulo, Brazil.

Weiner said the study model focused on how individual animals responded to alcohol. Typically, when a drug like alcohol is given to a mouse every day, the way the animals respond increases -- they become more stimulated and run around more. "In high doses, alcohol is a depressant, but in low doses, it can have a mellowing effect that results in greater activity," he said. "Those low dose effects tend to increase over time and this increase in activity in response to repeated alcohol exposure is called locomotor sensitization."

Prior studies with other drugs, such as cocaine and amphetamine, have suggested that animals that show the greatest increases in locomotor sensitization are also the animals most likely to seek out or consume these drugs. However, the relationship between locomotor sensitization and vulnerability to high levels of alcohol drinking is not as well established, Weiner said.

Usually when researchers are studying a drug, they give it to one test group while the other group gets a control solution, and then they look for behavioral differences between the two, Weiner said. But in this study, the researchers focused on individual differences in how each animal responded to the alcohol. A control group received a saline injection while another was injected with the same amount of alcohol every day for three weeks. Weiner said they used mice bred to be genetically variable like humans to make the research more relevant.

"We found large variations in the development of locomotor sensitization to alcohol in these mice, with some showing robust sensitization and others showing no more of a change in locomotor activity than control mice given daily saline injections," Weiner said. "Surprisingly, when all of the alcohol-exposed mice were given an opportunity to voluntarily drink alcohol, those that had developed sensitization drank more than those that did not. In fact, the alcohol-treated mice that failed to develop sensitization drank no more alcohol than the saline-treated control group."

The authors also conducted a series of neurobiological studies and discovered that mice that showed robust locomotor sensitization had deficits in a form of brain neuroplasticity -- how experiences reorganize neural pathways in the brain -- that has been linked with cocaine addiction in other animal models.

"We found that this loss of the ability of brain cells to change the way that they communicate with each other only occurred in the animals that showed the behavioral response to alcohol," he said. "What this suggests for the first time in the alcohol addiction field is that this particular deficit may represent an important brain correlate of vulnerability to alcoholism. It's a testable hypothesis. That's why I think it's an important finding."

Funding support for the research came from the National Institutes of Health (AA 21099, AA 17531, AA 10422 and AA 14445), Coordenadoria de Aperfeic?oamento de Pessoal de N?vel Superior (CAPES; Grant 0321-10-9), Fundac?a?o de Amparo a` Pesquisa do Estado de Sa?o Paulo (FAPESP; Grant 2008/01819-5), and Associac?a?o Fundo de Incentivo a`Pesquisa (AFIP).

The Translational Studies on Early-Life Stress and Vulnerability to Alcohol Addiction project is an NIH-funded collaborative grant which supports rodent, non-human primate and human studies investigating neurobiological mechanisms associated with vulnerability and resilience to alcohol addiction.

Co-authors include: Olusegun Ariwodola, Tracy Butler, Andrew Rau, Mary Jane Skelly, Eugenia Carter, Nancy Alexander and Brian McCool, all of Wake Forest Baptist, and Maria Lucia Formigoni of the Universidade de Sao Paulo.

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The above story is reprinted from materials provided by Wake Forest Baptist Medical Center.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. K. P. Abrahao, O. J. Ariwodola, T. R. Butler, A. R. Rau, M. J. Skelly, E. Carter, N. P. Alexander, B. A. McCool, M. L. O. Souza-Formigoni, J. L. Weiner. Locomotor Sensitization to Ethanol Impairs NMDA Receptor-Dependent Synaptic Plasticity in the Nucleus Accumbens and Increases Ethanol Self-Administration. Journal of Neuroscience, 2013; 33 (11): 4834 DOI: 10.1523/JNEUROSCI.5839-11.2013

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/top_health/~3/_N2uCTtYlAI/130325183810.htm

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Tuesday, March 26, 2013

New Features Add Functionality to 1 &1 MyWebsite

PHILADELPHIA, March 25, 2013 (GLOBE NEWSWIRE) -- 1 &1 Internet, Inc., www.1and1.com">www.1and1.com, a global leader among Web hosting providers, today unveiled a set of new inclusive features for its popular MyWebsite instant website package, designed to enhance both the appearance and capability of a small business website. 1 &1 is constantly adding new functionality to its MyWebsite packages in order to equip small companies with the best possible chance for online success.

As a result, 1 &1's new Video Maker tool enables a business to create audio-visual material they can publish on their website for a more persuasive sales approach. Within a few easy clicks, any level of user can create an online video from up to 20 images, and accompanied by a wide choice of royalty-free music. The feature is ideal for venues such as restaurants and hotels, or craftsmen who can showcase a portfolio of past work.

Brochures are another important tool for many companies in assisting consumers with their search for products or services.? If these brochures can be downloaded directly from the company website and printed, business owners save the time of fulfilling requests for information and save on the postage costs of sending these out.? 1 &1's new Online Brochure tool makes light work of creating such brochures.? Within seconds, the user can combine images and text to create a 32 page PDF brochure that their customers can view, save, print or share using buttons for Twitter, Facebook and Google+.

While the majority of business owners today do recognize the value of attracting and conducting business with customers online, few are using their own website to collect feedback or research their customers' needs.? Online surveys are an effective way to gain information in a number of areas such as customer satisfaction, effectiveness of their website, market research, demand for new offers, etc.?? In April, 1 &1 MyWebsite can help with its new Online Survey tool.? The App delivers professional looking online surveys to be embedded directly within a company homepage.?? Users can select from different survey templates that can be easily edited and customized.? A comprehensive report of results is provided online or emailed to the business owner in either PDF, Word, PowerPoint and Excel formats.

These new Apps are further examples of how 1 &1 actively advises small businesses on how to achieve a successful e-business strategy.? 1 &1 MyWebsite now offers more than 75 Web applications that can be integrated simply by 'drag-and-drop' into a website design to add functionality across eCommerce, communication, social media, or business management.? 1 &1 MyWebsite has already the widest selection of Web applications for rapid integration than any other website creation package and will continually add to the number of Web applications available.??

For more information about 1 &1 Internet, Inc., visit www.1and1.com">www.1and1.com.

About 1 &1 Internet Inc.:

1 &1 Internet Inc. is a subsidiary of United Internet, a profitable public company with a market cap of $3 billion. 1 &1 was founded in 1988 and hosts more than 11 million domain names, while more than 70,000 servers run in the company's five state-of-the-art, green data centers. 1 &1's global community is approximately 12 million customer contracts strong. The company's U.S. headquarters is located in Chesterbrook, Pa. For more information, visit www.1and1.com or contact the company at 1-877-GO-1AND1, on Facebook, or www.twitter.com/1and1.

For 1  &1 Internet Inc.: Kelly Meeneghan Phone: 610-560-1526 Fax: 610-560-1511   Courtney Pugh Phone: 610-560-1530 Fax: 610-560-1511

Source: http://globenewswire.com/news-release/2013/03/25/533461/10026272/en/New-Features-Add-Functionality-to-1-1-MyWebsite.html

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An app to end traffic jams?

Honda engineers are developing a technology that?detects the potential for a traffic jam and then determines the best course of action for drivers in order to prevent one from occurring, Vijayenthiran writes. Honda claims that by using the system, fuel economy can be improved by as much as 20 percent.

By Viknesh Vijayenthiran,?Guest blogger / March 26, 2013

Traffic stacks up on a highway in Dallas. Honda is developing an app aimed at reducing congestion and improving fuel efficiency.

LM Otero/AP/File

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About a year ago we first told you about a new?technology?Honda was developing?aimed at reducing congestion, by first detecting the potential for a traffic jam and then determining the best course of action for drivers in order to prevent one from occurring.

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It is based on the principle that?vehiclesmoving erratically and braking needlessly breaks up the smooth flow of traffic and leads to congestion.

Now, after conducting some real world tests on the busy streets of Jakarta, Indonesia, one of the most congested cities in the world, Honda engineers have managed to verify the effectiveness of the technology.

The system relies on the drivers of several vehicles all using a special smartphone app developed by Honda, which is connected to a cloud server (there is also a version for single users).?

Both sides plan rallies during same-sex marriage hearings

U.S. Supreme Court (Getty Images)

Thousands of activists on both sides of the gay marriage question are poised to rally outside the Supreme Court in Washington, D.C., starting on Tuesday while the justices hear oral arguments for two cases concerning same-sex marriage.

On Tuesday and Wednesday the court will hear arguments concerning the constitutionality of Proposition 8, a 2008 voter-approved law in California that banned gay marriage. On Wednesday the court will consider the Defense of Marriage Act, a law passed by Congress in 1996 that restricts the federal government from recognizing same-sex marriage.

Supporters and opponents of same-sex marriage are planning major rallies near the building to voice their views.

As early as last Thursday?five days before oral arguments begin?people began lining up near the court steps to secure seats inside, sitting through freezing temperatures, rain and snow over the weekend.

On Tuesday they will be joined by thousands more, some who are flying in from around the country for the hearings.

The National Organization for Marriage, which opposes extending marriage rights to same-sex couples, will hold a rally on the National Mall, a few blocks from the Supreme Court. The organization has a permit for 5,000 attendees to rally before marching together toward the court building. NOM has organized with church congregations from 15 states that have confirmed their planned attendance.

Supporters of same-sex marriage will also be on hand outside the court. The Human Rights Campaign, a leading gay advocacy group, is planning a diverse lineup of speakers throughout the morning, including a few Republicans who have crossed party lines to support extending marriage rights to gay and lesbian couples.

District of Columbia Delegate Eleanor Holmes Norton will address the pro-gay marriage rally, as will David Frum, a conservative journalist and former speechwriter for former President George W. Bush.

Yahoo News will be on hand both inside the court for hearing coverage and outside for the rallies. Follow live updates throughout the day on Flickr and join a live chat about the cases on Tuesday at 12:30 p.m. ET.

Source: http://news.yahoo.com/blogs/ticket/rallies-planned-outside-supreme-court-during-gay-marriage-215244762--politics.html

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T-Mobile's Sonic 2.0 mobile hotspot revealed, brings LTE-powered WiFi to the masses

TMobile's Sonic 20 mifi revealed, brings LTEpowered WiFi to the magenta loving massesT-Mobile's UnCarrier announcement event is taking place a little later today, but some bits of news have started to leak out ahead of time. First was the BlackBerry Z10, and now comes an LTE mobile hotspot, the Sonic 2.0. It's T-mo's first LTE mifi and can feed data to up to eight devices at a time. Not only that, it's compatible with both Mac OSX 10.8 and Windows 8, plus Microsofties get the added benefit of compatibility with the Win8 Carrier application so users can easily access real-time data usage info for every connected gadget. As for the hardware, the Sonic 2.0 has a 1.77-inch color LCD on the front, a 3,000 mAh battery, 802.11 b/g/n WiFi and quadband LTE and 3G radios on board. There's also a MicroSD card slot for simple file sharing of up to 32GB cards. It'll be available by the end of the month, though we don't yet know how much it'll cost. Guess you'll have to tune into our liveblog to find out.

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Via: Laptop Mag

Source: T-Mobile

Source: http://www.engadget.com/2013/03/26/t-mobiles-sonic-2-0-mifi-lte/

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Reputed Australian Mossad agent jailed after botched spy plan: papers

CANBERRA (Reuters) - An Australian emigrant and reputed Israeli spy who died in a jail in Israel in 2010 had been arrested after a bungled and unauthorized bid to recruit a double agent with links to Lebanon's Hezbollah, Australian newspapers reported on Monday.

The man, Ben Zygier, was arrested in early 2010 and was held in secret under the name of Prisoner X on unspecified security charges. A judicial inquiry in Israel found Zygier, 34, hanged himself in a high-security jail cell.

Israel has refused to disclose details of the case, even refusing a request for information from Australia's Department of Foreign Affairs and Trade, and the case has been the subject of gag orders in Israel.

But Australia's Fairfax newspapers and Germany's Der Spiegel magazine said after a joint investigation that Zygier had unwittingly given away secret information about Lebanese informants, who were later arrested and jailed in Lebanon.

"Zygier wanted to achieve something that he didn't end up getting," the Sydney Morning Herald quoted an unidentified, highly placed Israeli official as saying.

"Then he ended up on a precipitous path. He crossed paths with someone who was much more professional than he was."

The newspaper said Zygier, who took Israeli citizenship in the mid-1990s, was recruited to Israel's spy agency Mossad in 2004 and worked in Europe.

He was assigned to infiltrate companies with links to countries hostile to Israel, including Iran and Syria. It said Zygier was eventually pulled back to Tel Aviv and assigned to a desk job within Mossad.

In an attempt to prove himself and return to a field assignment, Zygier then set about trying to recruit a European man known to be close to Hezbollah militants, setting up meetings in late 2008 with the hope of recruiting the man as a double agent.

But the plan went wrong when Zygier tried to prove his credentials by giving up the names of Israel's top two Lebanese informants, Ziad al-Homsi and Mustafa Ali Awadeh, who were both arrested in 2009 and jailed for 15 years, the paper said.

When he was arrested in early 2010, Zygier was carrying a compact disc loaded with more intelligence files that he might have planned to pass on to his Hezbollah contact, the Sydney Morning Herald reported.

An Australian government inquiry earlier this month said it found no evidence any Australian passports had been misused by either Zygier, a dual Australian citizen, or by Mossad.

Australian Foreign Minister Bob Carr has confirmed Zygier was working for the Israeli government but stopped short of confirming he worked for Mossad.

(Reporting by James Grubel; Editing by Paul Tait)

Source: http://news.yahoo.com/reputed-australian-mossad-agent-jailed-botched-spy-plan-000007143.html

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Sunday, March 24, 2013

Spain police involved in 2 large cocaine raids

MADRID (AP) ? Spanish, Portuguese and British police boarded a ship loaded with nearly two tons of cocaine destined for sale in Europe and arrested nine people, the Interior Ministry said Saturday.

Specialist agents, including members of Britain's Serious Organized Crime Agency, conducted a dawn raid on March 15 while the ship was in the Atlantic Ocean, some 700 miles southwest of Portugal's Cape Verde islands.

"It is the largest operation so far in 2013 in our fight against drug trafficking," said Ignacio Cosido, Spain's director general of police.

Five crew aboard, four Brazilians and one Korean, were arrested and four alleged organizers ? including the suspected Venezuelan mastermind ? were rounded up the next day in the northern Portuguese city of Porto.

"He is a well-known person," Cosido said of the main suspect. "He has a background in drug trafficking and is an important member of that world."

Cocaine bales hidden in a bow locker and a backpack with a large amount in U.S. dollars were seized. The cocaine arrived at the naval dockyard of the Canary Island port of Las Palmas de Gran Canaria on Saturday, Cosido said.

The gang included a large group of Venezuela-based cocaine suppliers, the ministry statement said.

Earlier Saturday Spanish authorities said they had also seized 590 kilograms (1,300 pounds) of cocaine discovered inside a sailboat moored at a private dock and arrested two Eastern European men aboard.

The suspects were identified only as a 60-year-old Bulgarian and a 30-year-old from Serbia, one of whom was armed with a loaded 9mm pistol.

The operation began when a suspicious vessel sailing in international waters was found heading toward Spain's Mediterranean coast.

Agents observed the yacht entering the Sotogrande marina in southwestern Spain without lights and tying up at a private jetty. Investigators acting under instruction from a court in San Roque also searched several houses in that city and in Marbella.

The judicial authority ordered the suspects' imprisonment. The arrest took place last week but an exact date was not given.

Source: http://news.yahoo.com/spain-police-involved-2-large-cocaine-raids-175633253.html

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Chili and Chowder Competition Helps Children in Need of Therapy ...

Augusta - It may be spring, but this weather still calls for some chili to keep you warm.

The 12th annual Chili Chowder Challenge took place at the Augusta Armory on Saturday afternoon.

The event helps raise money for the Children's Center, an organization which helps young children with things like occupational or speech therapy.

This year, over 15 restaurants participated in the big cook off.

Exec. Dir., Children's Center, Jonathan Leach said "As our funding gets leaner every year, we're asked to do more with less. We really have to look to our local communities to kind of fill the gap between what it actually costs to provide quality service fees from the service that we get."

The Liberal Cup restaurant walked away winners today, but the big winner is the Children's Center. Organizers estimate they raised over $40,000.

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Source: http://www.wabi.tv/news/38690/chili-and-chowder-competition-helps-children-in-need-of-therapy

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Scientists reveal quirky feature of Lyme disease bacteria

Friday, March 22, 2013

Scientists have confirmed that the pathogen that causes Lyme Disease?unlike any other known organism?can exist without iron, a metal that all other life needs to make proteins and enzymes. Instead of iron, the bacteria substitute manganese to make an essential enzyme, thus eluding immune system defenses that protect the body by starving pathogens of iron.

To cause disease, Borrelia burgdorferi requires unusually high levels of manganese, scientists at Johns Hopkins University (JHU), Woods Hole Oceanographic Institution (WHOI), and the University of Texas reported. Their study, published March 22, 2013, in the Journal of Biological Chemistry, may explain some mysteries about why Lyme Disease is slow-growing and hard to detect and treat. The findings also open the door to search for new therapies to thwart the bacterium by targeting manganese.

"When we become infected with pathogens, from tuberculosis to yeast infections, the body has natural immunological responses," said Valeria Culotta, a molecular biologist at the JHU Bloomberg School of Public Health. The liver produces hepcidin, a hormone that inhibits iron from being absorbed in the gut and also prevents it from getting into the bloodstream. "We become anemic, which is one reason we feel terrible, but it effectively starves pathogens of iron they need to grow and survive," she said.

Borrelia, with no need for iron,has evolved to evade that defense mechanism. In 2000, groundbreaking research on Borrelia's genome by James Posey and Frank Gherardini at the University of Georgia showed that the bacterium has no genes that code to make iron-containing proteins and typically do not accumulate any detectable iron.

Culotta's lab at JHU investigates what she called "metal-trafficking" in organisms??the biochemical mechanisms that cells and pathogens such as Borrelia use to acquire and manipulate metal ions for their biological purposes.

"If Borrelia doesn't use iron, what does it use?" Culotta asked.

To find out, Culotta's lab joined forces with Mak Saito, a marine chemist at WHOI, who had developed techniques to explore how marine life uses metals. Saito was particularly intrigued because of the high incidence of Lyme Disease on Cape Cod, where WHOI is located, and because he specializes in metalloproteins, which contain iron, zinc, cobalt, and other elements often seen in vitamin supplements. The metals serve as linchpins, binding to enzymes. They help determine the enzymes' distinctive three-dimensional shapes and the specific chemical reactions they catalyze.

It's difficult to identify what metals are within proteins because typical analyses break apart proteins, often separating metal from protein. Saito used a liquid chromatography mass spectrometer to distinguish and measure separate individual Borrelia proteins according to their chemical properties and infinitesimal differences in their masses. Then he used an inductively coupled plasma mass spectrometer to detect and measure metals down to parts per trillion. Together, the combined analyses not only measured the amounts of metals and proteins, they showed that the metals are components of the proteins.

"The tools he has are fantastic," Culotta said. "Not too many people have this set of tools to detect metalloproteins."

The experiments revealed that instead of iron, Borrelia uses that element's next-door neighbor on the periodic chart, manganese, in certain Borrelia enzymes. These include an amino peptidase and an important antioxidant enzyme called superoxide dismutase.

Superoxide dismutase protects the pathogens against a second defense mechanism that the body throws against them. The body bombards pathogens with superoxide radicals, highly reactive molecules that cause damage within the pathogens. Superoxide dismutase is like an antioxidant that neutralizes the superoxides so that the pathogens can continue to grow.

The discoveries open new possibilities for therapies, Culotta said. "The only therapy for Lyme Disease right now are antibiotics like penicillin, which are effective if the disease is detected early enough. It works by attacking the bacteria's cell walls. But certain forms of Borrelia, such as the L-form, can be resistant because they are deficient in cell walls."

"So we'd like to find targets inside pathogenic cell that could thwart their growth," she continued. "The best targets are enzymes that the pathogens have, but people do not, so they would kill the pathogens but not harm people." Borrelia's distinctive manganese-containing enzymes such as superoxide dismutase may have such attributes.

In search of new avenues of attack, the groups are planning to expand their collaborative efforts by mapping out all the metal-binding proteins that Borellia uses and investigating biochemical mechanisms that the bacteria use to acquire manganese and directs it into essential enzymes. Knowing details of how that happens offers ways to disrupt the process and deter Lyme Disease.

###

Woods Hole Oceanographic Institution: http://www.whoi.edu

Thanks to Woods Hole Oceanographic Institution for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127404/Scientists_reveal_quirky_feature_of_Lyme_disease_bacteria

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Saturday, March 23, 2013

Debt management plan ? 3 Tips to make it work | Finance, Business ...

Debt management plan ? 3 Tips to make it work

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A debt management program is essentially an arrangement that you enter into with your credit counseling organization if you?re looking to get out of debt. Generally the organization you?re working with will be handling your debt management plan and work with your creditors to obtain lower rates of interest. They?ll then calculate a monthly payment amount that?s going to completely pay off your outstanding debt and that too within a specified period of time. Now, in spite of following a debt management plan many are unable to take care of their debts and this is essentially because people aren?t aware of making their debt management plans work.

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Tips to help you make a debt management plan work

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Enlisted below are 3 effective tips that?ll help you make your debt management plan work effectively.

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  1. 1.????? The right debt management company: This is one of the most important things you should keep in mind when planning to go in for debt management. The idea is to interview as many companies as possible before you sit down to work with a debt management company. You should call up the debt management companies and find out the services on offer. There are some companies that offer financial education materials, credit counseling, as well as money management advice as part of their debt management program. The idea is to choose a company that offers as many resources as possible before you get yourself enrolled into a plan.

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  1. 2.????? Commit to the right payment plan: It?s important that you commit to the right payment plan and that too depending on your income and monthly budget. Now, there are certain debt management plans that require you to make payments for around 30 to 60 months so that you can actually pay off all your debt. Now, be sure to account for those payments when you calculate your monthly expenses. Remember, you shouldn?t make the mistake of obligating yourself to monthly payments that you mightn?t be able to afford, for essentially this is a program that should help you get out of debt and not accrue further debt.

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  1. 3.????? Make your payments on time always: When you enroll into a debt management plan and opt for a monthly payment program, then you should make sure that you stick to it and not give up on it. Always make your payments on time. In case an emergency situation arises wherein you?re unable to make any particular payment, then inform your credit counseling company. This obviously allows the company a chance to restructure your payments so that you don?t suffer.

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Make your debt management plan work by keeping in mind the tips discussed above and you?ll soon see the light of financial freedom.

Source: http://www.openexport.biz/debt-management-plan-3-tips-to-make-it-work.php

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N.C. nixes pink-striped licenses for immigrants

RALEIGH, N.C. (AP) ? North Carolina said Thursday it is abandoning its plan to issue pink-striped driver's licenses to certain illegal immigrants, beset by mounting criticism of the specially designed IDs.

The state learned that such licenses are easier and more efficient to produce if they're similar to the traditional licenses issued to other drivers, said spokesman Mike Charbonneau at the state Transportation Department.

"My understanding is that when we're looking at that design, at the end of the day, we had to make sure we were following the letter of the law in the most efficient way possible," Charbonneau said.

In place of the proposed pink-striped design, the license is to look like the regular license issued to citizens save for words added in bold red letters: ""LEGAL PRESENCE / NO LAWFUL STATUS" and "LIMITED TERM."

The controversial original proposal also had included the phrase "NO LAWFUL STATUS."

The state will begin issuing the licenses Monday to young adults participating in the federal Deferred Action for Childhood Arrivals program. The Obama administration initiative grants valid federal work permits to qualified applicants brought as children to the U.S. without legal authorization.

The American Civil Liberties Union, Hispanic groups and others had criticized the pink-striped design proposal as singling out holders of that identification for possible discrimination and humiliation.

Jewish leaders also joined the outcry. Four rabbis had earlier made plans to hand-deliver a letter Friday to Gov. Pat McCrory asking him to scrap the pink-striped design. They said they would still deliver the letter anyway. It was signed by more than 70 Jewish leaders nationwide.

"Our efforts do not end when major discrimination turns into minor discrimination; it ends when we are 100 percent positive that discriminatory policies will not go into effect in our state," said Rabbi Eric Solomon of Raleigh's Beth Meyer Synagogue.

They said they were especially disturbed that the North Carolina Division of Motor Vehicles would begin issuing the licenses Monday, eve of the Jewish holiday Passover.

The state Attorney's General Office had said in January that state law requires the state to issue drivers' licenses to qualified applicants brought to the U.S. as children without legal authorization. State transportation officials had said they would abide by that decision, then unveiled the specially designed licenses.

McCrory had previously supported pink-striped licenses, saying in February that he signed off on what he called the "pragmatic compromise" unveiled by Transportation Secretary Tony Tata. McCrory had said the licenses must be clearly marked to prevent the bearer from accessing government services or registering to vote.

A McCrory spokeswoman said Thursday the governor supports the new design.

Raul Pinto, staff attorney with the North Carolina chapter of the American Civil Liberties Union, said the official decision to adopt a standard blue-striped license was "a huge step in the right direction."

But Pinto said his group still opposes the "NO LAWFUL STATUS" tag on the licenses and will keep monitoring whether it's "going to affect people in their everyday lives."

Democratic state Rep. Rick Glazier, who opposed the pink-striped design by co-sponsoring a bill against it in the General Assembly, said the pressure of public opinion appeared to be a factor in the change of plans.

The pink-striped license was "inherently discriminatory on its face" and would have humiliated any holder, Glazier added.

The Division of Motor Vehicles sent out a news release about plans to begin issuing the licenses starting Monday, but without mentioning the decision in the release. The design change was only evident in an attachment to the emailed release.

Jose Torres-Don, 25, of Carrboro, who is applying for the Deferred Action for Childhood Arrivals program, said he didn't really care about the style or color of the driver's license he receives.

A member of the NC Dream Team ? a group that advocates for young people brought to the U.S. unlawfully and seeking a path to citizenship ? Torres-Don said he just hopes the license uproar brings favorable attention to the plight of young people seeking proper documentation.

"What we ultimately seek is to drive without fear," he said. "We want to have a real conversation about how (being) undocumented is a problem."

___

Online:

To view new design: https://apps.ncdot.gov/newsreleases/details.aspx?r=7952

___

Martha Waggoner can be reached at http://twitter.com/mjwaggonernc

Source: http://news.yahoo.com/nc-scraps-proposed-pink-striped-license-001810341.html

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On The Internet, Everyone Knows You're A Dick

Boys ClubIn light of the recent PyCon debacle in which an offended party publicly shamed two developers at a conference for discussing dongles, I thought it would be interesting to address the problems of "lad culture" on the Internet (and, partially, the Silicon Valley/Alley societies) where wizards stay up late and make dick jokes over IRC.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/FIqNDgvqdxw/

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Thursday, March 21, 2013

Inherited genetic variations have a major impact on childhood leukemia risk

Mar. 19, 2013 ? Humans have between 20,000 and 25,000 genes that carry instructions for assembling the proteins that do the work of cells. Work led by St. Jude Children's Research Hospital found that children who inherit certain variations in four particular genes are at much higher risk of developing acute lymphoblastic leukemia (ALL).

The study also showed that Hispanic patients were more likely than patients of European or African ancestry to inherit high-risk versions of two of these genes. ALL rates are known to be higher among Hispanic children than those of European or African ancestry, this discovery points to at least one reason for that difference.

Each person's genome includes two copies of each gene, one from each parent. Thus, individuals could inherit up to eight high-risk versions of the four genes tied to an increased ALL risk. In this study, researchers found that having more than five copies of the risk genes resulted in a nine-fold greater risk of developing ALL in childhood than inheriting no more than one copy.

The report appears online March 19 in the Journal of the National Cancer Institute.

The findings stem from one of the largest multi-ethnic studies of genetic variation and ALL susceptibility ever conducted. The work included 2,450 pediatric ALL patients and 10,977 individuals from diverse racial and ethnic backgrounds without the disease.

The study's senior author, Jun J. Yang, Ph.D., an assistant member of the St. Jude Department of Pharmaceutical Sciences, said that the absolute risk for a particular child of developing ALL remains low. "ALL is a complex disease that likely involves many genes," he said. "The discoveries we are reporting in this paper are an important step forward in terms of understanding why children develop ALL in the first place, particularly for those with African or Hispanic ethnicity. However, this is probably still just a small part of the complete picture."

Along with providing insight into ethnicity and ALL risk, the study also offered clues to understanding the age pattern of ALL, which peaks in children ages 2 to 4. These findings suggest that younger patients might be most vulnerable to the effects of the high-risk gene variations.

This year about 3,000 children in the U.S. will be diagnosed with ALL, making it the most common childhood cancer. It is also among the most curable. Evidence that inheritance plays a role in childhood ALL risk has been building in recent years, but previous studies focused almost exclusively on patients of European ancestry. Thanks in part to new statistical methods for studying genetic variation in more diverse populations, this study expanded the quest to understand the genetic basis of ALL risk to include patients of African and Hispanic as well as European ancestry.

The effort involved ALL patients treated at St. Jude and through the Children's Oncology Group, the world's largest cooperative pediatric cancer research organization, As a comparison, investigators also screened DNA from individuals without ALL. Researchers used an automated system to check each person's DNA for 709,059 gene variations. In this study, ethnicity was assigned based on gene variations representative of European, African and Native American ancestry.

Previous studies from St. Jude and others linked pediatric ALL risk to common differences in the ARID5B, IKZF1, CEBPE and CDKN2A/2B genes. All play a role in normal blood and immune system development. ALL is a cancer of certain immune cells. In this study, researchers also discovered several variations in the gene PIP4K2A, which were associated with an elevated pediatric ALL risk. Hispanic patients were more likely than others in this study to inherit high-risk versions of the ARID5B and PIP4K2A genes, while African-American patients were less likely to have these variants.

The study's first authors are Heng Xu and Wenjian Yang, both of St. Jude. The other authors are Virginia Perez-Andreu, Yiping Fan, Cheng Cheng, Deqing Pei, Charles Mullighan, Deepa Bhojwani, Ching-Hon Pui, William Evans and Mary Relling, all of St. Jude; Meenakshi Devidas, University of Florida, Gainesville; Paul Scheet, University of Texas MD Anderson Cancer Center, Houston; Esteban Gonzalez Burchard, Celeste Eng, Scott Huntsman, Dara Torgerson and Mignon Loh, all of the University of California, San Francisco; Michael Dean, National Cancer Institute; Naomi Winick, University of Texas Southwestern Medical Center, Dallas; Paul Martin, Duke University, Durham, N.C.; Bruce Camitta, Medical College of Wisconsin; W. Paul Bowman, Cook Children's Medical Center, Ft. Worth; Cheryl Willman, University of New Mexico, Albuquerque; William Carroll, New York University; and Stephen Hunger, University of Colorado, Aurora.

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The above story is reprinted from materials provided by St. Jude Children's Research Hospital.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/jUB8fBTlyS0/130319201943.htm

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